To systematically review the prognostic value regarding the expression of long non-coding RNA (lncRNA) Hox transcript antisense intergenic RNA (HOTAIR) in patients with cancer. Methods: Databases including The Cochrane Library, EMBASE, MEDLINE, and PubMed were searched to collect English literature on the correlation between lncRNA HOTAIR expression and overall survival in tumors. The retrieval time was from inception to September 2015. After data were extracted, a Meta-analysis was performed using RevMan 5.3 software. Results: A total of 17 studies were included, which was involved in 1 639 patients. The Meta-analysis showed that high expression of HOTAIR could predict poor overall survival in cancer (HR: 2.39, 95% CI 2.01-2.86, P<0.001). High expression of HOTAIR could also predict poor overall survival both in digestive tumor (HR: 2.51, 95% CI 2.02-3.11, P<0.001) and non-digestive tumor (HR: 2.17, 95% CI 1.59-2.98, P<0.001). Moreover, overexpression of HOTAIR was found to be significantly associated with recurrence-free survival. Conclusion: The overexpression of lncRNA HOTAIR might be associated with poor prognosis in patients with cancer.
目的：系统评价长链非编码RNA(long non-coding RNA，lncRNA)HOTAIR表达水平与肿瘤患者预后的关系。方法：利用计算机检索The Cochrane Library，EMBASE，MEDLINE，PubMed等数据库中关于lncRNA HOTAIR表达与肿瘤预后相关性的英文文献，检索文献发表时间从建库到2015年9月，提取相关数据后采用RevMan5.3软件进行Meta分析。结果：最终纳入17篇文献，共1 639例患者。Meta分析结果显示：lncRNA HOTAIR高表达与肿瘤患者的低总生存期相关 (HR: 2.39，95% CI：2.01~2.86，P<0.001)；消化道肿瘤与非消化道肿瘤亚组分析均显示HOTAIR高表达患者总生存期缩短 (消化道肿瘤HR：2.51，95% CI：2.02~3.11，P<0.001。非消化道肿瘤HR：2.17，95% CI：1.59~2.98，P<0.001)。HOTAIR高表达与肿瘤患者的低无瘤复发生存期明显相关(HR：4.25，95% CI：2.25~8.03，P<0.001)。 结论：LncRNA HOTAIR高表达与肿瘤的不良预后有一定的关系。.