Hacking the Matrix

Michael Czerwinski; Jason R Spence

doi:10.1016/j.stem.2016.12.010

Hacking the Matrix

Cell Stem Cell. 2017 Jan 5;20(1):9-10. doi: 10.1016/j.stem.2016.12.010.

Authors

Michael Czerwinski¹, Jason R Spence²

Affiliations

¹ Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109-5624, USA.
² Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109-5624, USA; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109-5624, USA; Center for Organogenesis, University of Michigan Medical School, Ann Arbor, MI 48109-5624, USA. Electronic address: spencejr@umich.edu.

Abstract

Recently in Nature, Gjorevski et al. (2016) describe a fully defined synthetic hydrogel that mimics the extracellular matrix to support in vitro growth of intestinal stem cells and organoids. The hydrogel allows exquisite control over the chemical and physical in vitro niche and enables identification of regulatory properties of the matrix.

Publication types

Comment

MeSH terms

Extracellular Matrix / chemistry
Hydrogel, Polyethylene Glycol Dimethacrylate / analysis*
Intestines
Organoids*
Stem Cells

Substances

Hydrogel, Polyethylene Glycol Dimethacrylate

Abstract

Publication types

MeSH terms

Substances

Grants and funding