Elevation of the levels of SmB, B' and D proteins but not that of the La (SS-B) antigen during HSV infections

N G Sharpe; D Isenberg; D G Williams; D S Latchman

doi:10.1016/s0896-8411(89)80008-3

Elevation of the levels of SmB, B' and D proteins but not that of the La (SS-B) antigen during HSV infections

J Autoimmun. 1989 Oct;2(5):701-8. doi: 10.1016/s0896-8411(89)80008-3.

Authors

N G Sharpe¹, D Isenberg, D G Williams, D S Latchman

Affiliation

¹ Department of Biochemistry, University College, Middlesex School of Medicine, London, UK.

PMID: 2803478
DOI: 10.1016/s0896-8411(89)80008-3

Abstract

Three Sm proteins, B, B' and D, which are highly immunoreactive in systemic lupus erythematosus (SLE), increase in abundance in Vero cells infected with laboratory strains and clinical isolates of herpes simplex virus (HSV) types 1 and 2. The autoimmune antigen La (SS-B) does not accumulate in identical infections. The significance of the Sm antigen accumulation is discussed in terms of its possible role in HSV infection and in connection with the origin of autoantibodies in SLE.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autoantigens / biosynthesis*
Autoimmune Diseases / immunology
Gene Expression Regulation
Herpes Simplex / immunology*
Humans
Lupus Erythematosus, Systemic / immunology
Models, Biological
Ribonucleoproteins*
Ribonucleoproteins, Small Nuclear*
SS-B Antigen
Vero Cells / immunology
snRNP Core Proteins

Substances

Autoantigens
Ribonucleoproteins
Ribonucleoproteins, Small Nuclear
SNRPB protein, human
snRNP Core Proteins