Stimuli-responsive nanocomposites for magnetic targeting synergistic multimodal therapy and T1/T2-weighted dual-mode imaging

Yinyin Chen; Xiaoran Deng; Chunxia Li; Fei He; Bei Liu; Zhiyao Hou; Ziyong Cheng; Bengang Xing; Jun Lin

doi:10.1016/j.nano.2016.12.004

Stimuli-responsive nanocomposites for magnetic targeting synergistic multimodal therapy and T₁/T₂-weighted dual-mode imaging

Nanomedicine. 2017 Apr;13(3):875-883. doi: 10.1016/j.nano.2016.12.004. Epub 2016 Dec 18.

Authors

Yinyin Chen¹, Xiaoran Deng¹, Chunxia Li², Fei He¹, Bei Liu¹, Zhiyao Hou³, Ziyong Cheng³, Bengang Xing⁴, Jun Lin⁵

Affiliations

¹ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China; University of the Chinese Academy of Sciences, Beijing, PR China.
² State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China. Electronic address: cxli@ciac.ac.cn.
³ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China.
⁴ School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore.
⁵ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China. Electronic address: jlin@ciac.ac.cn.

PMID: 27993724
DOI: 10.1016/j.nano.2016.12.004

Abstract

Anticancer drug doxorubicin hydrochloride (DOX)-loaded photothermal nanocomposite MnFe₂O₄@mSiO₂ with magnetic targeting and T₁/T₂-weighted dual-mode magnetic resonance imaging of MnFe₂O₄ core and NIR/pH-coupling sensitive mesoporous silica shell nanocarriers was designed and synthesized successfully. The anticancer drug DOX can be absorbed into mesoporous layer of MnFe₂O₄@mSiO₂ nanocomposite, which shows obvious photothermal/chemo dual-modal synergistic therapies triggered by NIR/pH. Under 808 nm irradiation, MnFe₂O₄ can transform light into thermo, which can not only ablate tumor cells directly but also promote chemotherapy drugs releasing from mesoporous layer to kill tumor cells. The lower pH can also promote DOX releasing from mesoporous layer to enhance tumor inhibitory effect. It is confirmed that biocompatible DOX-MnFe₂O₄@mSiO₂ nanocomposites can act as a potential multifunctional platform for effective magnetic targeting photothermal/chemo dual-modal synergistic therapies with enhanced anti-tumor efficacy and T₁/T₂-weighted dual-mode magnetic resonance imaging (MRI) applications in vivo.

Keywords: Dual-mode imaging; Magnetic targeting; Stimuli-responsive; Synergistic therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / therapeutic use
Combined Modality Therapy / methods
Delayed-Action Preparations / chemistry
Delayed-Action Preparations / therapeutic use
Doxorubicin / administration & dosage*
Doxorubicin / therapeutic use
Drug Delivery Systems / methods*
Ferric Compounds / chemistry*
Ferric Compounds / therapeutic use
HeLa Cells
Humans
Hyperthermia, Induced / methods
Magnetic Fields
Magnetic Resonance Imaging / methods*
Manganese Compounds / chemistry*
Manganese Compounds / therapeutic use
Mice
Nanocomposites / chemistry*
Nanocomposites / therapeutic use
Nanocomposites / ultrastructure
Neoplasms / diagnostic imaging
Neoplasms / therapy*
Phototherapy / methods
Silicon Dioxide / chemistry*
Silicon Dioxide / therapeutic use

Substances

Antineoplastic Agents
Delayed-Action Preparations
Ferric Compounds
Manganese Compounds
manganese ferrite
Silicon Dioxide
Doxorubicin