Extracellular functions of 14-3-3 adaptor proteins

Andrew Kaplan; Mardja Bueno; Alyson E Fournier

doi:10.1016/j.cellsig.2016.12.007

Extracellular functions of 14-3-3 adaptor proteins

Cell Signal. 2017 Feb:31:26-30. doi: 10.1016/j.cellsig.2016.12.007. Epub 2016 Dec 18.

Authors

Andrew Kaplan¹, Mardja Bueno², Alyson E Fournier²

Affiliations

¹ Department of Neurology and Neurosurgery, Montréal Neurological Institute, McGill University, Montréal, Québec, H3A 2B4, Canada. Electronic address: andrew.kaplan@mail.mcgill.ca.
² Department of Neurology and Neurosurgery, Montréal Neurological Institute, McGill University, Montréal, Québec, H3A 2B4, Canada.

PMID: 27993556
DOI: 10.1016/j.cellsig.2016.12.007

Abstract

14-3-3s are a family of adaptor proteins with a wide range of roles in cell signaling. Although they are primarily localized within the cytosol, 14-3-3s are also known to be present in the extracellular environment. Externalization of 14-3-3 can occur as a result of cell death or physiologically via release in exosomes. Interesting biological activities with relevance for tissue homeostasis and disease are now being described for extracellular 14-3-3s. Moreover, aminopeptidase N (APN) has been identified as a cell surface receptor for 14-3-3s. Here we review the array of bioactivities that have been ascribed to extracellular 14-3-3s and discuss applications as biomarkers and as targets for drug development.

Keywords: 14-3-3; APN; Biomarker; CD13; Exosome; MMP; Stratifin.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

14-3-3 Proteins / chemistry
14-3-3 Proteins / metabolism*
Amino Acid Sequence
Disease
Extracellular Space / metabolism*
Homeostasis
Humans
Wound Healing

Substances

14-3-3 Proteins

Grants and funding

CIHR/Canada