IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

Jeroen Slaats; Jaap Ten Oever; Frank L van de Veerdonk; Mihai G Netea

doi:10.1371/journal.ppat.1005973

IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

PLoS Pathog. 2016 Dec 15;12(12):e1005973. doi: 10.1371/journal.ppat.1005973. eCollection 2016 Dec.

Authors

Jeroen Slaats¹, Jaap Ten Oever¹, Frank L van de Veerdonk¹, Mihai G Netea¹

Affiliation

¹ Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

Abstract

The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response. Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for guiding the diagnosis and management of infectious diseases. This review discusses the profiles of acute-phase proteins and circulating cytokines encountered in viral and bacterial infections. We also propose a model in which the inflammatory response to viral (IL-18/ferritin) and bacterial (IL-6/CRP) infections presents with specific plasma patterns of immune biomarkers.

Publication types

Review

MeSH terms

Acute-Phase Proteins / immunology*
Animals
Bacterial Infections / immunology*
C-Reactive Protein / immunology
Cytokines / immunology*
Ferritins / immunology
Humans
Inflammation / immunology*
Inflammation Mediators / immunology
Interleukin-18 / immunology
Interleukin-1beta / immunology
Interleukin-6 / immunology
Virus Diseases / immunology*

Substances

Acute-Phase Proteins
Cytokines
Inflammation Mediators
Interleukin-18
Interleukin-1beta
Interleukin-6
C-Reactive Protein
Ferritins

Grants and funding

MGN was supported by an ERC Consolidator Grant (#310372). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.