Reduced Transplacental Transfer of Group B Streptococcus Surface Protein Antibodies in HIV-infected Mother-Newborn Dyads

J Infect Dis. 2017 Feb 1;215(3):415-419. doi: 10.1093/infdis/jiw566.

Abstract

We evaluated the effect of maternal HIV infection on transplacental antibody transfer specific to 8 group B Streptococcus (GBS) surface proteins among 81 HIV-uninfected and 83 HIV-infected mother-newborn pairs using a multiplex immunoassay. Significantly lower antibody titers were detected in HIV-infected mothers and HIV-exposed uninfected newborns compared to HIV-uninfected mother-newborn dyads. Maternal HIV infection was also associated with reduced transplacental transfer of antibodies for Sip (25.8%), Foldase (30.4%), gba0392 (36.5%), gbs0393 (32.9%), gbs1539 (39.2%), gbs2106 (35.7%), and BibA (19.4%); P < .003. This reduced transplacental antibody might contribute to increased susceptibility for invasive GBS disease in HIV-exposed uninfected infants.

Keywords: HIV; antibodies; group B Streptococcus; surface proteins; trans-placental transfer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / blood*
  • Antibodies, Viral / blood*
  • Female
  • HIV Infections / immunology*
  • HIV-1 / genetics
  • Humans
  • Immunity, Maternally-Acquired*
  • Immunoassay
  • Infant, Newborn / immunology
  • Maternal-Fetal Exchange / immunology
  • Membrane Proteins / immunology*
  • Multivariate Analysis
  • Pregnancy
  • Pregnancy Complications, Infectious / immunology*
  • Pregnancy Complications, Infectious / virology
  • Regression Analysis
  • South Africa
  • Streptococcus agalactiae
  • Viral Load

Substances

  • Antibodies, Bacterial
  • Antibodies, Viral
  • Membrane Proteins