Long-Term Real-Time In Vivo Drug Release Monitoring with AIE Thermogelling Polymer

Abstract

A new drug concentration meter is developed. In vivo drug release can be monitored precisely via a self-indicating drug delivery system consisting of a new aggregation-induced emission thermoresponsive hydrogel. By taking the advantage of a self-indicating system, one can easily detect the depletion of drugs, and reinject to maintain a dosage in the optimal therapeutic window.

Keywords: AIE micelles; drug delivery; fluorescence dyes; imaging; thermogels.