Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1

Biochem Soc Trans. 2016 Dec 15;44(6):1683-1693. doi: 10.1042/BST20160161.

Abstract

Protein phosphatase 2A (PP2A) plays a major role in maintaining cellular signaling homeostasis by dephosphorylation of a variety of signaling proteins and acts as a tumor suppressor. Protein phosphatase methylesterase-1 (PME-1) negatively regulates PP2A activity by highly complex mechanisms that are reviewed here. Importantly, recent studies have shown that PME-1 promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance. We discuss the emerging cancer-associated function of PME-1 and its potential clinical relevance.

Keywords: LCMT-1; PTPA; colorectal cancer; endometrial cancer; glioma; neuroendocrine prostate cancer.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carboxylic Ester Hydrolases / metabolism*
  • Humans
  • Methylation
  • Models, Biological
  • Neoplasms / enzymology
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Phosphorylation
  • Protein Phosphatase 2 / metabolism*
  • Signal Transduction*
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Tumor Suppressor Proteins
  • Carboxylic Ester Hydrolases
  • protein phosphatase methylesterase-1
  • Protein Phosphatase 2