Myeloid-derived suppressor cells and their role in pancreatic cancer

Cancer Gene Ther. 2017 Mar;24(3):100-105. doi: 10.1038/cgt.2016.65. Epub 2016 Dec 2.

Abstract

Pancreatic cancer is a devastating disease and ranks as the third most common cause of cancer-related death. Like many cancers, there has been increased interest in the role of the immune system in the progression and development of pancreatic cancer. In particular, immunosuppression within the tumor microenvironment (TME) is thought to impair the host's antitumor response. In this article, we review myeloid-derived suppressor cells and their contribution to this immunosuppression within the pancreatic TME.

Publication types

  • Review

MeSH terms

  • Animals
  • Carcinoma, Pancreatic Ductal / immunology
  • Carcinoma, Pancreatic Ductal / metabolism
  • Carcinoma, Pancreatic Ductal / pathology
  • Cell Communication
  • Cell Movement / immunology
  • Cell Proliferation
  • Humans
  • Immunologic Surveillance
  • Immunomodulation
  • Macrophages / immunology
  • Macrophages / metabolism
  • Macrophages / pathology
  • Molecular Targeted Therapy
  • Myeloid-Derived Suppressor Cells / drug effects
  • Myeloid-Derived Suppressor Cells / immunology*
  • Myeloid-Derived Suppressor Cells / metabolism*
  • Myeloid-Derived Suppressor Cells / pathology
  • Pancreatic Neoplasms / immunology*
  • Pancreatic Neoplasms / metabolism*
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / therapy
  • Phenotype
  • Signal Transduction
  • Tumor Microenvironment / immunology