Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons

Blood. 2017 Jan 12;129(2):260-263. doi: 10.1182/blood-2016-10-746727. Epub 2016 Dec 1.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Anemia, Sickle Cell / blood*
  • Anemia, Sickle Cell / drug therapy*
  • Animals
  • Drug Evaluation, Preclinical
  • Enzyme Inhibitors / adverse effects
  • Enzyme Inhibitors / pharmacology*
  • Fetal Hemoglobin / metabolism*
  • Histone Demethylases / antagonists & inhibitors*
  • Papio
  • Rhodamines / adverse effects
  • Rhodamines / pharmacology*
  • Spiro Compounds / adverse effects
  • Spiro Compounds / pharmacology*
  • Thiophenes / adverse effects
  • Thiophenes / pharmacology*

Substances

  • Enzyme Inhibitors
  • RN1 compound
  • Rhodamines
  • Spiro Compounds
  • Thiophenes
  • Fetal Hemoglobin
  • Histone Demethylases