Objective: To characterize the migration patterns of men who have sex with men (MSM) living with HIV/AIDS in the period 2008-2015 and to characterize the determinants of their migration. Methods: All identified HIV/AIDS cases transmitted through self-reported homosexual contact reported to the National Case Reporting System(CRS) by the end of December 31, 2015 were included in this study. Data of basic demographic characteristics, household registration and address of the research objects were collected. Retrospective cohort study was used to analyze the migration characteristics of HIV/AIDS cases between 2008 and 2015.We used the χ2 test to analyze their migration patterns and epidemiological characteristics, and multilevel logistic regression to investigate the determinants of migration. Results: While mobile cases comprised 46.1% of the sample (n=54 714), we detected a significant rising trend (χ2=130.93, P<0.001) as this proportion rose from 42.0% (1 335/3 182) in 2008 to 47.9% (15 623/32 610) in 2015. Of the 13 580 mobile cases with Hukou registration in Eastern China, 89.8% (12 201) migrated to other parts of Eastern China. Meanwhile, 52.0% of the 26 088 cases registered in Central China (n=13 570) and 30.5% of the 14 106 registered in Western China (n=4 298) migrated to Eastern China. Furthermore, 96.2% of mobile cases (n=52 627) resided in the urban areas, of which 40.8% (n=21 452) migrated from rural areas to urban areas and 58.4% (n=30 722) migrated between urban areas. The annual proportion of cases who changed their address within 1 year of diagnosis ranged from 12.0%-18.5%. The results of the multilevel model showed that cases who were aged 25-49 years (OR=1.30, 95% CI: 1.26-1.34), single (OR=1.95, 95% CI: 1.87-2.02), and had a high school education or above (OR=1.68, 95% CI: 1.64-1.73) were more likely to migrate. AIDS (OR=0.71, 95% CI: 0.69-0.74), Hukou registration in an urban area (OR=0.63, 95%CI: 0.61-0.65), in Central China (OR=0.84, 95%CI: 0.73-0.97), Western China (OR=0.75, 95%CI: 0.64-0.87), and in regions with a high population density or above-average gross domestic product (GDP) per head (OR=0.77, 95% CI: 0.69-0.87 and OR=0.70, 95% CI: 0.62-0.79, respectively) were negatively associated with migration. Conclusion: The number and proportion of mobile HIV cases showed a rising annual trend. Age, marital status, level of education and disease severity, in addition to the population density and level of economic development of cases' place of origin, were significant determinants of migration.