The BALB/c mouse infection model for improving the Haemophilus parasuis serotyping scheme

Jiang Yu; Yuyu Zhang; Yijun Du; Jun Li; Baohua Huang; Wenbo Sun; Xiaoyan Cong; Jun Peng; Sufang Ren; Lihui Gou; Jianli Shi; Zhi Chen; Lei Chen; Jianda Li; Jie Yang; Jiaqiang Wu; Jinbao Wang

doi:10.1016/j.rvsc.2016.10.011

The BALB/c mouse infection model for improving the Haemophilus parasuis serotyping scheme

Res Vet Sci. 2016 Dec:109:166-168. doi: 10.1016/j.rvsc.2016.10.011. Epub 2016 Oct 24.

Authors

Jiang Yu¹, Yuyu Zhang¹, Yijun Du¹, Jun Li¹, Baohua Huang¹, Wenbo Sun¹, Xiaoyan Cong¹, Jun Peng², Sufang Ren¹, Lihui Gou¹, Jianli Shi¹, Zhi Chen¹, Lei Chen¹, Jianda Li¹, Jie Yang¹, Jiaqiang Wu³, Jinbao Wang⁴

Affiliations

¹ Shandong Academy of Agricultural Sciences, Jinan, People's Republic of China; Shandong Key Lab of Animal Disease Control and Breeding, Jinan, People's Republic of China.
² Shandong Academy of Agricultural Sciences, Jinan, People's Republic of China; Shandong Key Lab of Animal Disease Control and Breeding, Jinan, People's Republic of China; College of Veterinary Medicine, Shandong Agricultural University, Taian, People's Republic of China.
³ Shandong Academy of Agricultural Sciences, Jinan, People's Republic of China; Shandong Key Lab of Animal Disease Control and Breeding, Jinan, People's Republic of China. Electronic address: wujiaqiang2000@sina.com.
⁴ Shandong Academy of Agricultural Sciences, Jinan, People's Republic of China; Shandong Key Lab of Animal Disease Control and Breeding, Jinan, People's Republic of China. Electronic address: wangjb@saas.ac.cn.

PMID: 27892867
DOI: 10.1016/j.rvsc.2016.10.011

Abstract

The use of BALB/c mouse as an alternative model to study Haemophilus parasuis (HPS) infections was evaluated, supplying the serotyping scheme by comparing the pathogenicity of different serovar HPS in pigs and mice challenge using statistical analysis. Results showed that the pathogenicity of different serovar HPS in mouse was consistent with in pigs, proving that this model is a viable alternative to pigs. It provides a convenient methodology for determining the virulence of HPS strains.

Keywords: BALB/c mouse; Haemophilus parasuis; Model.

MeSH terms

Animals
Female
Haemophilus Infections / veterinary*
Haemophilus Infections / virology
Haemophilus parasuis / classification
Haemophilus parasuis / pathogenicity*
Haemophilus parasuis / physiology*
Mice
Mice, Inbred BALB C
Models, Animal
Serogroup
Serotyping / veterinary
Swine
Swine Diseases / virology*
Virulence