Vitamin D Receptor TaqI Gene Polymorphism and Dental Caries in Czech Children

Caries Res. 2017;51(1):7-11. doi: 10.1159/000452635. Epub 2016 Nov 26.

Abstract

Aim: We analyzed the VDR TaqI (rs731236) gene polymorphism in children with and those without dental caries.

Methods: A total of 388 subjects, 153 caries-free (with decayed/missing/filled teeth [DMFT] = 0) and 235 children with dental caries (DMFT ≥1), were genotyped by the TaqMan method.

Results: Although no significant differences in VDR TaqI allele and genotype frequencies between caries-free and caries-affected children were detected, a significant association between this polymorphism and gingivitis was found (p < 0.05).

Conclusions: In contrast to previous studies from China and Turkey, the VDR TaqI gene variant cannot be used as a marker for identification of Czech children with increased dental caries risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alleles
  • Case-Control Studies
  • Czech Republic / epidemiology
  • DMF Index
  • Dental Caries / epidemiology
  • Dental Caries / genetics*
  • Deoxyribonucleases, Type II Site-Specific
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Gingivitis / epidemiology
  • Gingivitis / genetics*
  • Humans
  • Male
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Receptors, Calcitriol / genetics*

Substances

  • Receptors, Calcitriol
  • VDR protein, human
  • Deoxyribonucleases, Type II Site-Specific
  • TCGA-specific type II deoxyribonucleases