TP53 and 53BP1 Reunited

Thierry Soussi; Guido Kroemer

doi:10.1016/j.tcb.2016.10.004

TP53 and 53BP1 Reunited

Trends Cell Biol. 2017 May;27(5):311-313. doi: 10.1016/j.tcb.2016.10.004. Epub 2016 Nov 17.

Authors

Thierry Soussi¹, Guido Kroemer²

Affiliations

¹ Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK) R8:04, Stockholm SE-171 76, Sweden; Department of Life Sciences, Université Pierre et Marie Curie, Paris, France; INSERM U1138, Centre de Recherche des Cordeliers, Paris, France; Equipe11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. Electronic address: thierry.soussi@ki.se.
² Department of Life Sciences, Université Pierre et Marie Curie, Paris, France; INSERM U1138, Centre de Recherche des Cordeliers, Paris, France; Equipe11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Université Paris Descartes, Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

PMID: 27866833
DOI: 10.1016/j.tcb.2016.10.004

Abstract

Identified as a TP53-binding protein, 53BP1 is a key regulator of the cellular response to double-strand breaks, a TP53-independent activity. Recent data have established a new TP53-dependent function for 53BP1 in mitotic surveillance after centrosome loss.

Keywords: 53BP1; TP53; cell cycle; checkpoints.

MeSH terms

Centrosome / metabolism
Humans
Models, Biological
Mutation / genetics
Tumor Suppressor Protein p53 / metabolism*
Tumor Suppressor p53-Binding Protein 1 / metabolism*

Substances

Tumor Suppressor Protein p53
Tumor Suppressor p53-Binding Protein 1