Conservative and Pharmacologic Treatments for the Diabetic Charcot Foot

Nina L Petrova; Michael E Edmonds

doi:10.1016/j.cpm.2016.07.003

Conservative and Pharmacologic Treatments for the Diabetic Charcot Foot

Clin Podiatr Med Surg. 2017 Jan;34(1):15-24. doi: 10.1016/j.cpm.2016.07.003. Epub 2016 Sep 19.

Authors

Nina L Petrova¹, Michael E Edmonds²

Affiliations

¹ Diabetic Foot Clinic, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK. Electronic address: petrovanl@yahoo.com.
² Diabetic Foot Clinic, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.

PMID: 27865311
DOI: 10.1016/j.cpm.2016.07.003

Abstract

Charcot neuroarthropathy is a disabling complication of diabetic neuropathy. Prolonged immobilization in a total contact cast (TCC) is among the main treatments. Education of health care professionals in the application of TCC together with well-conducted clinical trials are required to overcome its frequent underuse. There are no established pharmacologic therapies to treat this condition; however, there is an overwhelming need for a new therapeutic approach. Novel targeted drug delivery systems are required to prevent the pathologic bone and joint destruction of the Charcot neuroarthropathy and this may lead to an improved outcome in diabetic patients with this condition.

Keywords: Casting therapy; Charcot neuroarthropathy; Diabetes mellitus; Disease activity; MRI.

Publication types

Review

MeSH terms

Arthropathy, Neurogenic / diagnosis
Arthropathy, Neurogenic / etiology
Arthropathy, Neurogenic / therapy*
Diabetic Foot / diagnosis
Diabetic Foot / etiology
Diabetic Foot / therapy*
Foot Joints
Humans