Rationale: Oral anticoagulants and painkillers, some with an additional effect on the coagulation system, are widely used and are therefore prone to abuse and (intentional) overdose. We report the case of a patient with a massive mixed anticoagulant intoxication.
Patient concerns: The patient had ingested 1960 mg rivaroxaban, 31.5 mg phenprocoumon, 1425 mg diclofenac, and 21,000 mg metamizole in suicidal intention.
Diagnoses: Massive mixed anticoagulant overdose.
Interventions: The patient was closely monitored. The phenprocoumon overdose was treated by the administration of vitamin K and PCC.
Outcomes: Despite the massive inhibition of the coagulation system, the patient did not experience bleeding apart from a slight gross hematuria.
Lessons: Despite the ingestion of a massive amount of rivaroxaban, the plasma levels were not as high as feared, due to the ceiling effect of rivaroxaban absorption. Elimination occurred according to the half-life of rivaroxaban and was not unduly prolonged by the ingested quantity.