Abstract
The present study investigated the relationship between exposure to infectious agents and inflammation markers in individuals with schizophrenia (SZ), bipolar disorder (BP), and controls without a psychiatric disorder. We measured plasma levels of antibodies and innate immune markers and correlated them with clinical symptoms and cognitive function. In both SZ and BP, we found an increase in soluble CD14, and in BP an increase in C-reactive protein, IgM class antibodies against cytomegalovirus (CMV), and IgG class antibodies against herpes simplex virus 2. Furthermore in BP, we observed a negative relationship between IgG antibodies against CMV and scores for cognitive function.
Keywords:
Antibody level; Bipolar disorder; Inflammation; Neurocognition; Schizophrenia.
Copyright © 2016 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.
MeSH terms
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Adult
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Antibodies, Protozoan / blood*
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Antibodies, Viral / blood*
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Biomarkers / blood
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Bipolar Disorder / blood
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Bipolar Disorder / complications
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Bipolar Disorder / parasitology*
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Bipolar Disorder / virology*
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C-Reactive Protein / analysis*
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Case-Control Studies
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Cytomegalovirus / immunology
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Female
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Herpesvirus 1, Human / immunology
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Herpesvirus 2, Human / immunology
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Humans
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Infections / blood
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Infections / complications
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Infections / parasitology
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Infections / virology
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Inflammation / blood
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Lipopolysaccharide Receptors / blood*
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Male
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Middle Aged
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Schizophrenia / blood
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Schizophrenia / complications
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Schizophrenia / parasitology*
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Schizophrenia / virology*
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Serum Amyloid P-Component / analysis*
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Toxoplasma / immunology
Substances
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Antibodies, Protozoan
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Antibodies, Viral
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Biomarkers
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Lipopolysaccharide Receptors
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Serum Amyloid P-Component
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PTX3 protein
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C-Reactive Protein