Microtubule Affinity-Regulating Kinase 2 (MARK2) protein has a substantial role in regulation of vital cellular processes like induction of polarity, regulation of cell junctions, cytoskeleton structure and cell differentiation. The abnormal function of this protein has been associated with a number of pathological conditions like Alzheimer disease, autism, several carcinomas and development of virulent effects of Helicobacter pyloriββαβββ.
Keywords: Auto-inhibition; Kinase protein regulation; MARK2; Molecular dynamics simulation; Molecular modeling; UBA domain.