Short-Term Adverse Outcomes After Deep Brain Stimulation Treatment in Patients with Parkinson Disease

Kejia Hu; Ziev B Moses; Matthew M Hutter; Ziv Williams

doi:10.1016/j.wneu.2016.10.138

Short-Term Adverse Outcomes After Deep Brain Stimulation Treatment in Patients with Parkinson Disease

World Neurosurg. 2017 Feb:98:365-374. doi: 10.1016/j.wneu.2016.10.138. Epub 2016 Nov 5.

Authors

Kejia Hu¹, Ziev B Moses², Matthew M Hutter³, Ziv Williams⁴

Affiliations

¹ Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Microsurgery, Huashan Hospital, Fudan University, Shanghai, China.
² Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
³ Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
⁴ Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: zwilliams@mgh.harvard.edu.

PMID: 27826085
DOI: 10.1016/j.wneu.2016.10.138

Abstract

Background: Despite ongoing progress in our understanding of long-term outcomes after neuromodulation procedures, acute adverse outcomes shortly after deep brain stimulation (DBS) treatment have remained remarkably limited.

Objective: To identify risk factors associated with acute 30-day outcomes after DBS treatment in patients with Parkinson disease (PD).

Methods: We evaluated patients who underwent DBS treatment for PD from 2005 to 2014 through the American College of Surgeons National Surgical Quality Improvement Program database. We used bivariate analysis and multivariate logistic regression to identify short-term postoperative outcomes, including 30-day complication, discharge destination, and unplanned readmission.

Results: Overall, 650 patients with PD underwent DBS procedures and complications were identified in 32 patients (4.9%). Of 481 patients who had complete discharge data, 18 patients (3.7%) were discharged to a facility and 16 patients (3.3%) experienced an unplanned readmission. Patients with PD who were obese (P = 0.045), who had preoperative anemia (P = 0.008), and who experienced longer operative durations (P = 0.01) had increased odds of postoperative complications. Inpatient status (P = 0.001), dependent functional status (P < 0.001), and anemia (P = 0.043) were all associated with discharge to a facility other than home. Longer operative duration (P = 0.013), anemia (P = 0.036), and dependent functional status (P = 0.03) were significantly associated with unplanned readmission. As expected, complications increased the likelihood of unplanned readmission (P < 0.001).

Conclusions: This study provides individualized estimates of the risks associated with short-term adverse outcomes based on patient demographics and comorbidities. These data can be used as an adjunct for short-term risk stratification of patients with PD being considered for DBS treatment.

Keywords: Complication; Deep brain stimulation; Discharge destination; NSQIP; Parkinson disease; Unplanned readmission.

MeSH terms

Aged
Cohort Studies
Deep Brain Stimulation / adverse effects*
Deep Brain Stimulation / trends*
Female
Humans
Male
Middle Aged
Parkinson Disease / diagnosis
Parkinson Disease / epidemiology*
Parkinson Disease / therapy*
Patient Readmission / trends
Postoperative Complications / diagnosis
Postoperative Complications / epidemiology*
Registries
Time Factors
Treatment Outcome