The Human Functional Genomics Project: Understanding Generation of Diversity

Jenna L Pappalardo; David A Hafler

doi:10.1016/j.cell.2016.10.040

The Human Functional Genomics Project: Understanding Generation of Diversity

Cell. 2016 Nov 3;167(4):894-896. doi: 10.1016/j.cell.2016.10.040.

Authors

Jenna L Pappalardo¹, David A Hafler²

Affiliations

¹ Departments of Immunobiology and Neurology, Yale School of Medicine, New Haven, CT 06520, USA.
² Departments of Immunobiology and Neurology, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: david.hafler@yale.edu.

PMID: 27814519
DOI: 10.1016/j.cell.2016.10.040

Abstract

Generation of biologic diversity is a cornerstone of immunity, yet the tools to investigate the causal influence of genetic and environmental factors have been greatly limited. Studies from the Human Functional Genomics Project, presented in Cell and other Cell Press journals, integrate environmental and genetic factors with the direction and magnitude of immune responses to decipher inflammatory disease pathogenesis.

Publication types

Comment

MeSH terms

Environment*
Genomics*
Humans

Grants and funding

T32 AI007019/AI/NIAID NIH HHS/United States