Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia

Haematologica. 2017 Mar;102(3):e80-e84. doi: 10.3324/haematol.2016.155655. Epub 2016 Nov 3.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD34 / genetics
  • Antigens, CD34 / metabolism
  • Butyric Acid / pharmacology
  • Cell Culture Techniques
  • Enzyme Inhibitors / pharmacology*
  • Erythroid Cells / cytology
  • Erythroid Cells / drug effects*
  • Erythroid Cells / metabolism
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Histone Demethylases / antagonists & inhibitors
  • Histone Demethylases / genetics*
  • Histone Demethylases / metabolism
  • Histones / genetics
  • Histones / metabolism
  • Humans
  • Hydroxamic Acids / pharmacology
  • Hydroxyquinolines / pharmacology*
  • Hydroxyurea / pharmacology
  • Molecular Sequence Annotation
  • Piperazines / pharmacology
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / metabolism
  • Small Molecule Libraries / pharmacology*
  • Tranylcypromine / pharmacology
  • Vorinostat
  • alpha-Globins / antagonists & inhibitors
  • alpha-Globins / genetics*
  • alpha-Globins / metabolism
  • beta-Thalassemia / drug therapy
  • beta-Thalassemia / enzymology
  • beta-Thalassemia / genetics
  • beta-Thalassemia / pathology

Substances

  • Antigens, CD34
  • Enzyme Inhibitors
  • Histones
  • Hydroxamic Acids
  • Hydroxyquinolines
  • Piperazines
  • RNA, Small Interfering
  • Small Molecule Libraries
  • alpha-Globins
  • Butyric Acid
  • chaetocin
  • Tranylcypromine
  • Vorinostat
  • Histone Demethylases
  • 5-carboxy-8-hydroxyquinoline
  • Hydroxyurea