Cancer of the Esophagus and Esophagogastric Junction: An Eighth Edition Staging Primer

Thomas W Rice; Hemant Ishwaran; Mark K Ferguson; Eugene H Blackstone; Peter Goldstraw

doi:10.1016/j.jtho.2016.10.016

Cancer of the Esophagus and Esophagogastric Junction: An Eighth Edition Staging Primer

J Thorac Oncol. 2017 Jan;12(1):36-42. doi: 10.1016/j.jtho.2016.10.016. Epub 2016 Oct 31.

Authors

Thomas W Rice¹, Hemant Ishwaran², Mark K Ferguson³, Eugene H Blackstone⁴, Peter Goldstraw⁵

Affiliations

¹ Cleveland Clinic, Cleveland, Ohio. Electronic address: ricet@ccf.org.
² University of Miami, Miami, Florida.
³ The University of Chicago, Chicago, Illinois.
⁴ Cleveland Clinic, Cleveland, Ohio.
⁵ National Heart and Lung Institute, Imperial College, London, United Kingdom.

Abstract

This primer for eighth edition staging of esophageal and esophagogastric epithelial cancers presents separate classifications for the clinical (cTNM), pathologic (pTNM), and postneoadjuvant pathologic (ypTNM) stage groups, which are no longer shared. For pTNM, pT1 has been subcategorized as pT1a and pT1b for the subgrouping pStage I adenocarcinoma and squamous cell carcinoma. A new, simplified esophagus-specific regional lymph node map has been introduced. Undifferentiated histologic grade (G4) has been eliminated; additional analysis is required to expose histopathologic cell type. Location has been removed as a category for pT2N0M0 squamous cell cancer. The definition of the esophagogastric junction has been revised. ypTNM stage groups are identical for both histopathologic cell types, unlike those for cTNM and pTNM.

Keywords: AJCC/UICC eighth edition staging; Esophageal cancer; Esophagogastric cancer; Staging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / pathology*
Carcinoma, Squamous Cell / pathology*
Esophageal Neoplasms / pathology*
Esophagogastric Junction / pathology*
Humans
Neoplasm Grading
Neoplasm Staging / standards*
Prognosis

Abstract

Publication types

MeSH terms

Grants and funding