Predictive value of serum pregnancy-associated plasma protein A for patients with ischemic cerebrovascular disease

J Clin Lab Anal. 2017 Sep;31(5):e22091. doi: 10.1002/jcla.22091. Epub 2016 Nov 3.

Abstract

Background: To investigate the role of pregnancy-associated plasma protein A (PAPP-A) in the outcome of ischemic cerebrovascular disease.

Methods: We analyzed the levels of PAPP-A in the transient ischemic attack (TIA) patients, ischemic stroke (IS) patients and normal control, and followed up the outcome of the patients in the following 2 years. Blood samples were drawn at admission, prior to treatment with heparins.

Results: The levels of PAPP-A in TIA patients, IS patients and normal control were 4.91 (2.11, 6.48) mIU/L, 6.77 (3.31, 10.23) mIU/L and 4.25 (1.76, 5.22) mIU/L, respectively. The follow-up results of TIA patients and IS patients indicated the PAPP-A concentration in the poor prognosis group were higher than those in the good prognosis group (5.90 vs 4.46 mIU/L, P<.05, 10.06 vs 5.12 mIU/L, P<.05, respectively). Serum PAPP-A concentration emerged as a predictor of risk stratification with an OR of 1.41 and 1.25 (P<.05, P<.05).

Conclusions: Higher PAPP-A concentration has a forecasting value on prognosis in ischemic cerebrovascular disease.

Keywords: biomarker; inflammation; ischemic stroke; pregnancy-associated plasma protein-A; transient ischemic attack.

MeSH terms

  • Aged
  • Biomarkers / blood*
  • Brain Ischemia* / blood
  • Brain Ischemia* / diagnosis
  • Brain Ischemia* / epidemiology
  • Case-Control Studies
  • Female
  • Humans
  • Inflammation
  • Ischemic Attack, Transient* / blood
  • Ischemic Attack, Transient* / diagnosis
  • Ischemic Attack, Transient* / epidemiology
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Pregnancy-Associated Plasma Protein-A / analysis*

Substances

  • Biomarkers
  • Pregnancy-Associated Plasma Protein-A