We review the Kauzmann paradox and what it implies about the configuration space energy hypersurface for "structural glassformers." With this background, we then show how the relaxation expression of Adam and Gibbs qualitatively accounts for most of the phenomenology of liquid and polymeric glassformers including the strong/fragile liquid pattern, and the behavior of non-ergodic systems. Extended temperature range relaxation studies are consistent with a relaxation time pre-exponent on the quasi-lattice vibration time scale. When this boundary condition is imposed on Vogel-Fulcher-Tammann fittings, correspondence of T0 with TK is found for liquids with Tg ranging over 1000 K. When it is imposed on the WLF equation C1 is obliged to become ~16, and the corresponding force-fitted C2 provides a measure of the polymer fragility which is generally not available from thermodynamic studies. Systems which exhibit discontinuous changes in configurational entropy on temperature increase, which include unfolding proteins, are briefly reviewed.
Keywords: energy landscapes; fragility; glass formers; glass transition; protein folding; relaxation.