Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics

Wei Tao; Xianbing Zhu; Xinghua Yu; Xiaowei Zeng; Quanlan Xiao; Xudong Zhang; Xiaoyuan Ji; Xusheng Wang; Jinjun Shi; Han Zhang; Lin Mei

doi:10.1002/adma.201603276

Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics

Adv Mater. 2017 Jan;29(1):10.1002/adma.201603276. doi: 10.1002/adma.201603276. Epub 2016 Oct 31.

Authors

Wei Tao^{1

2

3

4}, Xianbing Zhu^{1

2}, Xinghua Yu¹, Xiaowei Zeng^{1

2}, Quanlan Xiao³, Xudong Zhang^{1

2}, Xiaoyuan Ji⁴, Xusheng Wang^{1

2}, Jinjun Shi⁴, Han Zhang³, Lin Mei^{1

2}

Affiliations

¹ Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China.
² School of Life Sciences, Tsinghua University, Beijing, 100084, China.
³ Shenzhen Key Laboratory of Two-Dimensional Materials and Devices (SKTMD), SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen, 518060, China.
⁴ Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Abstract

2D black phosphorus (BP) nanomaterials are presented as a delivery platform. The endocytosis pathways and biological activities of PEGylated BP nanosheets in cancer cells are revealed for the first time. Finally, a triple-response combined therapy strategy is achieved by PEGylated BP nanosheets, showing a promising and enhanced antitumor effect.

Keywords: black phosphorus; enhanced cancer therapies; nanosheets; theranostic delivery platforms.

MeSH terms

Humans
Nanostructures
Neoplasms
Phosphorus / chemistry*
Theranostic Nanomedicine

Substances

Phosphorus

Abstract

MeSH terms

Substances

Grants and funding