Treatment patterns in moderate-to-severe plaque psoriasis: results from a Belgian cross-sectional study (DISCOVER)

J Dermatolog Treat. 2017 Aug;28(5):394-400. doi: 10.1080/09546634.2016.1255304. Epub 2016 Nov 15.

Abstract

Purpose: The present study aimed to evaluate current treatment patterns and achievement of treatment goals in Belgian patients with moderate-to-severe plaque psoriasis.

Materials and methods: This cross-sectional observational study (DISCOVER) was conducted in 2011 - 2012 in Belgian dermatology centers. Patient data were collected during a single visit and included information on psoriasis management and severity (PASI and DLQI). Treatment success was defined according to the current European consensus treatment goal algorithm.

Results: Of the 556 patients included in the study, 38.1% reported no current treatment or only topicals, 34.2% were being treated with traditional systemics and/or phototherapy, and 29.5% with biologics. Methotrexate (11.7%) was the most commonly prescribed traditional systemic and adalimumab (14.2%) was the most commonly prescribed biologic agent at the time of the study. The percentage of patients achieving treatment goals was significantly higher in biologic-treated patients (73.1%) compared to those using traditional systemics (50.6%), phototherapy (41.1%), or no treatment/only topicals (20.9%; p < .001).

Conclusions: Nearly 40% of Belgian patients with moderate-to-severe psoriasis in the DISCOVER study were undertreated despite the severity of their disease. Undertreatment of psoriasis remains a problem in Belgium and more effective educational strategies are needed to ensure the best treatment outcome for these patients. [Formula: see text].

Keywords: Epidemiological survey; psoriasis treatment; real-life setting; treatment goals.

MeSH terms

  • Adalimumab / therapeutic use
  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Belgium
  • Biological Products / therapeutic use*
  • Cross-Sectional Studies
  • Dermatologic Agents / therapeutic use*
  • Female
  • Humans
  • Male
  • Methotrexate / therapeutic use
  • Middle Aged
  • Phototherapy
  • Psoriasis / drug therapy
  • Psoriasis / pathology
  • Psoriasis / therapy*
  • Severity of Illness Index
  • Treatment Outcome
  • Young Adult

Substances

  • Biological Products
  • Dermatologic Agents
  • Adalimumab
  • Methotrexate