Aortic Valve Calcification and the Risk of dementia: A Population-Based Study

J Alzheimers Dis. 2017;55(3):893-897. doi: 10.3233/JAD-160871.

Abstract

The association of aortic valve calcification (AVC) with dementia remains unknown. In 2,428 non-demented participants from the population-based Rotterdam Study, we investigated the association of CT-assessed AVC with risk of dementia and cognitive decline. AVC was present in 33.1% of the population. During a median follow-up of 9.3 years, 160 participants developed dementia. We found no association between presence of AVC and risk of all-cause dementia [hazard ratio (HR): 0.89 (95% confidence interval (CI):0.63;1.26)]. Presence of AVC was not associated with cognitive decline on any of the cognitive tests, nor with a measure of global cognition.

Keywords: Aortic valve pathology; calcification; dementia; epidemiology; imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aortic Valve / diagnostic imaging
  • Aortic Valve / pathology*
  • Aortic Valve Stenosis / diagnostic imaging
  • Aortic Valve Stenosis / epidemiology*
  • Calcinosis / diagnostic imaging
  • Calcinosis / epidemiology*
  • Cohort Studies
  • Community Health Planning
  • Dementia / diagnostic imaging
  • Dementia / epidemiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Tomography, X-Ray Computed

Supplementary concepts

  • Aortic Valve, Calcification of