PKA Has the Gall to Oppose NLRP3

Christina J Groß; Olaf Groß

doi:10.1016/j.immuni.2016.09.019

PKA Has the Gall to Oppose NLRP3

Immunity. 2016 Oct 18;45(4):707-709. doi: 10.1016/j.immuni.2016.09.019.

Authors

Christina J Groß¹, Olaf Groß²

Affiliations

¹ Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
² Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany. Electronic address: olaf.gross@tum.de.

PMID: 27760332
DOI: 10.1016/j.immuni.2016.09.019

Abstract

The involvement of the NLRP3 inflammasome in inflammatory diseases has generated interest in identifying endogenous mechanisms that inhibit NLRP3. In this issue of Immunity, Guo et al. (2016) reveal bile acids as negative regulators of the NLRP3 inflammasome.

Publication types

Review
Comment

MeSH terms

Animals
Cyclic AMP-Dependent Protein Kinases / immunology*
Cyclic AMP-Dependent Protein Kinases / metabolism*
Humans
Inflammasomes / immunology
Inflammasomes / metabolism
Inflammation / immunology
Inflammation / metabolism
NLR Family, Pyrin Domain-Containing 3 Protein / immunology*
NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
Cyclic AMP-Dependent Protein Kinases