Targeting acetaldehyde dehydrogenase 2 (ALDH2) in heart failure-Recent insights and perspectives

Jiaojiao Pang; Jiali Wang; Yingmei Zhang; Feng Xu; Yuguo Chen

doi:10.1016/j.bbadis.2016.10.004

Targeting acetaldehyde dehydrogenase 2 (ALDH2) in heart failure-Recent insights and perspectives

Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):1933-1941. doi: 10.1016/j.bbadis.2016.10.004. Epub 2016 Oct 11.

Authors

Jiaojiao Pang¹, Jiali Wang², Yingmei Zhang³, Feng Xu⁴, Yuguo Chen⁵

Affiliations

¹ Department of Emergency, Qilu Hospital, Shandong University, Jinan, China; Chest Pain Center, Qilu Hospital, Shandong University, Jinan, China; Institute of Emergency and Critical Care Medicine, Shandong University, Jinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong University, Jinan, China; Key Laboratory of Cardiovascular Remodeling & Function Research, Chinese Ministry of Education & Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China. Electronic address: jiaojiaopang@126.com.
² Department of Emergency, Qilu Hospital, Shandong University, Jinan, China; Chest Pain Center, Qilu Hospital, Shandong University, Jinan, China; Institute of Emergency and Critical Care Medicine, Shandong University, Jinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong University, Jinan, China; Key Laboratory of Cardiovascular Remodeling & Function Research, Chinese Ministry of Education & Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China. Electronic address: wangjiali_2000@126.com.
³ Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China; Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY, USA.
⁴ Department of Emergency, Qilu Hospital, Shandong University, Jinan, China; Chest Pain Center, Qilu Hospital, Shandong University, Jinan, China; Institute of Emergency and Critical Care Medicine, Shandong University, Jinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong University, Jinan, China; Key Laboratory of Cardiovascular Remodeling & Function Research, Chinese Ministry of Education & Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China. Electronic address: xufengsdu@126.com.
⁵ Department of Emergency, Qilu Hospital, Shandong University, Jinan, China; Chest Pain Center, Qilu Hospital, Shandong University, Jinan, China; Institute of Emergency and Critical Care Medicine, Shandong University, Jinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong University, Jinan, China; Key Laboratory of Cardiovascular Remodeling & Function Research, Chinese Ministry of Education & Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China. Electronic address: chen919085@126.com.

PMID: 27742538
DOI: 10.1016/j.bbadis.2016.10.004

Abstract

Heart failure is one of the major causes of the ever-rising mortality globally. ALDH2 rs671 polymorphism is proven to be closely related to the prevalence of CAD, hypertension, diabetes mellitus and alcoholism, which are etiological factors of heart failure. In addition, growing evidence supports a possible role for ALDH2 in different forms of heart failure. In this mini-review, we will review the recent insights regarding the effects of ALDH2 polymorphism on etiological factors of heart failure and underlying mechanisms involved. In addition, we will also discuss the booming epigenetic information in this field which will greatly improve our understanding of the cardiovascular effect of ALDH2. This article is part of a Special Issue entitled: Genetic and epigenetic control of heart failure edited by Dr. Jun Ren & Yingmei Zhang.

Keywords: ALDH2; Epigenetic regulation; Genetic polymorphism; Heart failure.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aldehyde Dehydrogenase, Mitochondrial* / antagonists & inhibitors
Aldehyde Dehydrogenase, Mitochondrial* / genetics
Aldehyde Dehydrogenase, Mitochondrial* / metabolism
Animals
Drug Delivery Systems*
Epigenesis, Genetic*
Heart Failure* / drug therapy
Heart Failure* / genetics
Heart Failure* / metabolism
Humans
Polymorphism, Genetic*

Substances

ALDH2 protein, human
Aldehyde Dehydrogenase, Mitochondrial