Isolation and characterization of roridin E

Clark D Ridge; Eugene P Mazzola; Martyn P Coles; Simon F R Hinkley

doi:10.1002/mrc.4539

Isolation and characterization of roridin E

Magn Reson Chem. 2017 Apr;55(4):337-340. doi: 10.1002/mrc.4539. Epub 2016 Nov 10.

Authors

Clark D Ridge¹, Eugene P Mazzola¹, Martyn P Coles², Simon F R Hinkley²

Affiliations

¹ Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, 20740, USA.
² The Ferrier Research Institute, School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand.

PMID: 27737497
DOI: 10.1002/mrc.4539

Abstract

The commonly occurring, high-cytotoxicity macrolide roridin E has been re-isolated from Stachybotrys chartarum and characterized by 1-D and 2-D NMR spectroscopy. Assignment of the spectral data for roridin E revealed differences from the accepted literature, and spectra are reported herein to aid in future identification. For the first time confirmation of structure was provided by a crystallographic solution for roridin E. Copyright © 2016 John Wiley & Sons, Ltd.

Keywords: NMR analysis; roridin E; trichothecene.