Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells

Cold Spring Harb Symp Quant Biol. 1978:42 Pt 2:649-57. doi: 10.1101/sqb.1978.042.01.067.
No abstract available

MeSH terms

  • Alleles
  • Cell Line
  • Dose-Response Relationship, Drug
  • Drug Resistance
  • Enzyme Induction / drug effects
  • Genes / drug effects*
  • Methotrexate / pharmacology*
  • Nucleic Acid Hybridization
  • RNA, Messenger / metabolism
  • Tetrahydrofolate Dehydrogenase / genetics*

Substances

  • RNA, Messenger
  • Tetrahydrofolate Dehydrogenase
  • Methotrexate