Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces

Tao Yu; Jane Chisholm; Woo Jin Choi; Abraham Anonuevo; Sarah Pulicare; Weixi Zhong; Minmin Chen; Colleen Fridley; Samuel K Lai; Laura M Ensign; Jung Soo Suk; Justin Hanes

doi:10.1002/adhm.201600599

Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces

Adv Healthc Mater. 2016 Nov;5(21):2745-2750. doi: 10.1002/adhm.201600599. Epub 2016 Sep 26.

Authors

Tao Yu^{1

2}, Jane Chisholm^{1

3}, Woo Jin Choi², Abraham Anonuevo³, Sarah Pulicare³, Weixi Zhong², Minmin Chen¹, Colleen Fridley³, Samuel K Lai⁴, Laura M Ensign^{1

3

5}, Jung Soo Suk^{1

5}, Justin Hanes^{1

2

3

5}

Affiliations

¹ Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA.
² Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
³ Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD, 21218, USA.
⁴ Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Campus box 7362, Chapel Hill, NC, 27599, USA.
⁵ Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD, 21297, USA.

Abstract

Mucus-penetrating nanosuspensions, consisting of pure hydrophobic therapeutics with dense muco-inert coatings that enable particles to effectively bypass the mucus barrier, demonstrate superior drug distribution and absorption at mucosal surfaces. With significantly increased drug load compared to polymeric systems and established clinical translation of nanosuspensions-based products, mucus-penetrating nanosuspensions are a promising vehicle for improving mucosal delivery of poorly soluble drugs.

Keywords: curcumin; drug delivery; mucus penetrating particles; nanocrystals; nanotechnology.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Drug Delivery Systems / methods
Humans
Mucus / metabolism*
Nanoparticles / administration & dosage*
Nanoparticles / chemistry*
Pharmaceutical Preparations / administration & dosage*
Pharmaceutical Preparations / chemistry*
Solubility
Suspensions / administration & dosage*

Substances

Pharmaceutical Preparations
Suspensions

Abstract

Publication types

MeSH terms

Substances

Grants and funding