Cu-Catalyzed hydrophosphorylative ring opening of propargyl epoxides: highly selective access to 4-phosphoryl 2,3-allenols

Chem Commun (Camb). 2016 Sep 29;52(80):11959-11962. doi: 10.1039/c6cc05428e.

Abstract

A novel CuI-catalyzed cross-coupling of propargyl epoxides with P(O)H compounds is disclosed. The reaction proceeded efficiently under mild conditions to give 4-phosphoryl 2,3-allenols in good to high yields with excellent selectivity. The utility of the products was demonstrated and a plausible mechanism was also proposed.