HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and poor prognosis in a Chinese population

Future Oncol. 2017 Feb;13(4):347-355. doi: 10.2217/fon-2016-0290. Epub 2016 Oct 3.

Abstract

Aim: The aim of this study was to determine if HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and prognosis.

Materials & methods: The data were obtained from two independent groups including 329 ovarian cancer patients and 680 cancer-free, age-matched women. Blood samples were collected and genomic DNA was extracted for genotyping.

Results: TT genotype and T allele of HOTAIR rs920778 were significantly associated with a decreased ovarian cancer risk (p = 0.0004 and p < 0.0001, respectively), which associated with advanced tumor stage, lymph node metastasis and poor prognosis. Moreover, TT and TC carriers obtained a much shorter survival (p = 0.026).

Conclusion: These findings propose that HOTAIR rs920778 polymorphism influences ovarian cancer susceptibility and prognosis, and further studies are warranted in other populations.

Keywords: HOTAIR; cancer susceptibility; long noncoding RNA; ovarian cancer; prognosis; rs920778 polymorphism.

MeSH terms

  • Adult
  • Aged
  • Alleles*
  • Asian People / genetics*
  • Case-Control Studies
  • China
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Kaplan-Meier Estimate
  • Lymphatic Metastasis
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Staging
  • Odds Ratio
  • Ovarian Neoplasms / diagnosis
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / mortality*
  • Ovarian Neoplasms / therapy
  • Polymorphism, Single Nucleotide*
  • Prognosis
  • RNA, Long Noncoding / genetics*

Substances

  • HOTAIR long untranslated RNA, human
  • RNA, Long Noncoding