Disrupted latent decision processes in medication-free pediatric OCD patients

J Affect Disord. 2017 Jan 1:207:32-37. doi: 10.1016/j.jad.2016.09.011. Epub 2016 Sep 20.

Abstract

Background: Decision-making in Obsessive Compulsive Disorder has typically been investigated in the adult population. Computational approaches have recently started to get integrated into these studies. However, decision-making research in pediatric OCD populations is scarce.

Methods: We investigated latent decision processes in 21 medication-free pediatric OCD patients and 23 healthy control participants. We hypothesized that OCD patients would be more cautious and less efficient in evidence accumulation than controls in a two alternative forced choice (2AFC) task.

Results: Pediatric OCD patients were less efficient than controls in accumulating perceptual evidence and showed a tendency to be more cautious. In comparison to post-correct decisions, OCD patients increased decision thresholds after erroneous decisions, whereas healthy controls decreased decision thresholds. These changes were coupled with weaker evidence accumulation after errors in both groups.

Limitations: The small sample size limited the power of the study.

Conclusions: Our results demonstrate poorer decision-making performance in pediatric OCD patients at the level of latent processes, specifically in terms of evidence accumulation.

Keywords: Children; Decision making; Hierarchical Drift Diffusion Model; Obsessive Compulsive Disorder.

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Child
  • Choice Behavior
  • Decision Making*
  • Female
  • Humans
  • Male
  • Obsessive-Compulsive Disorder / psychology*
  • Risk-Taking*