Tip60: Main Functions and Its Inhibitors

Mini Rev Med Chem. 2017;17(8):675-682. doi: 10.2174/1389557516666160923125031.

Abstract

Background: Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates.

Results: Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers.

Conclusion: Here, main functions and its known inhibitors were summarized.

Keywords: Cancer; HATs; HDACs; Tip60; histone acetyltransferase; inhibitor; ε-amino.

Publication types

  • Review

MeSH terms

  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Histone Acetyltransferases / antagonists & inhibitors*
  • Histone Acetyltransferases / metabolism*
  • Humans
  • Lysine Acetyltransferase 5
  • Models, Molecular
  • Molecular Structure

Substances

  • Enzyme Inhibitors
  • Histone Acetyltransferases
  • KAT5 protein, human
  • Lysine Acetyltransferase 5