Meal associated changes in brown fat thermogenesis and glycogen

Physiol Behav. 1989 Feb;45(2):243-8. doi: 10.1016/0031-9384(89)90125-x.

Abstract

Data indicate a close association between a decrease in feeding-induced brown adipose tissue (BAT) thermogenesis and an increase in food consumption. The present study examines the hypothesis that feeding-induced BAT thermogenesis, or feeding-induced changes in BAT glycogen, a mobile form of energy store and a correlate of BAT thermogenesis, may modulate feeding behavior. We report that propranolol, which completely abolished meal-induced BAT thermogenesis, did not evoke intake of a larger meal. Though BAT glycogen concentration is a sensitive measure of the state of feeding, on a meal to meal basis it does not correlate with hunger and satiety. Hence the hypothesis is not supported by the current data. We also report that meal-induced BAT hypertrophy and glycogen deposition can be dissociated from meal-induced BAT thermogenesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adipose Tissue, Brown / analysis
  • Adipose Tissue, Brown / drug effects
  • Adipose Tissue, Brown / metabolism*
  • Animals
  • Behavior, Animal / physiology
  • Feeding Behavior / physiology*
  • Glycogen / analysis*
  • Guanine Nucleotides / metabolism*
  • Guanosine Diphosphate / metabolism*
  • Liver / analysis
  • Male
  • Muscles / analysis
  • Propranolol / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Time Factors

Substances

  • Guanine Nucleotides
  • Guanosine Diphosphate
  • Glycogen
  • Propranolol