Psychiatric and Cognitive Effects of Deep Brain Stimulation for Parkinson's Disease

Adam Nassery; Christina A Palmese; Harini Sarva; Mark Groves; Joan Miravite; Brian Harris Kopell

doi:10.1007/s11910-016-0690-1

Psychiatric and Cognitive Effects of Deep Brain Stimulation for Parkinson's Disease

Curr Neurol Neurosci Rep. 2016 Oct;16(10):87. doi: 10.1007/s11910-016-0690-1.

Authors

Adam Nassery¹, Christina A Palmese², Harini Sarva³, Mark Groves², Joan Miravite^{2

4}, Brian Harris Kopell⁵

Affiliations

¹ Saul Korey Department of Neurology, Albert Einstein College of Medicine, 111 E 210 Street, Bronx, NY, 10467, USA.
² Department of Neurology, Division of Movement Disorders, Mount Sinai Beth Israel, 10 Union Square E, New York, NY, 10003, USA.
³ Division of Neurology, Maimonides Medical Center, 883 65th Street, Brooklyn, NY, 11220, USA. sarvaharini@gmail.com.
⁴ Division of Neurology, Maimonides Medical Center, 883 65th Street, Brooklyn, NY, 11220, USA.
⁵ Department of Neurosurgery, Mount Sinai Health System, 1468 Madison Avenue, New York, NY, 10029, USA.

PMID: 27539167
DOI: 10.1007/s11910-016-0690-1

Abstract

Deep brain stimulation (DBS) is effective for Parkinson's disease (PD), dystonia, and essential tremor (ET). While motor benefits are well documented, cognitive and psychiatric side effects from the subthalamic nucleus (STN) and globus pallidus interna (GPi) DBS for PD are increasingly recognized. Underlying disease, medications, microlesions, and post-surgical stimulation likely all contribute to non-motor symptoms (NMS).

Keywords: Affective disorders; Cognition; Deep brain stimulation; Parkinson’s disease.

Publication types

Review

MeSH terms

Cognitive Dysfunction / etiology*
Cognitive Dysfunction / therapy
Deep Brain Stimulation / adverse effects*
Globus Pallidus*
Humans
Mental Disorders / etiology*
Parkinson Disease / complications
Parkinson Disease / therapy*
Subthalamic Nucleus*