The role of Trim25 in development, disease and RNA metabolism

Biochem Soc Trans. 2016 Aug 15;44(4):1045-50. doi: 10.1042/BST20160077.

Abstract

Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of pre-let-7. Here we review the current knowledge of the role of Trim25 in development, disease and RNA metabolism.

Keywords: E3 ubiquitin ligase; RNA metabolism; Trim25; novel RNA-binding proteins.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Disease / genetics*
  • Female
  • Humans
  • Mice
  • Models, Genetic
  • RNA / genetics*
  • RNA / metabolism
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Tripartite Motif Proteins / genetics*
  • Tripartite Motif Proteins / metabolism
  • Ubiquitin-Protein Ligases / genetics*
  • Ubiquitin-Protein Ligases / metabolism
  • Uterus / growth & development
  • Uterus / metabolism*

Substances

  • DNA-Binding Proteins
  • Transcription Factors
  • Trim25 protein, mouse
  • Tripartite Motif Proteins
  • RNA
  • TRIM25 protein, human
  • Ubiquitin-Protein Ligases