Translocation 3;21 in Philadelphia chromosome positive chronic myeloid leukemia at diagnosis

P W Thompson; J A Whittaker

doi:10.1016/0165-4608(89)90178-7

Translocation 3;21 in Philadelphia chromosome positive chronic myeloid leukemia at diagnosis

Cancer Genet Cytogenet. 1989 Jun;39(2):143-6. doi: 10.1016/0165-4608(89)90178-7.

Authors

P W Thompson¹, J A Whittaker

Affiliation

¹ Department of Haematology, University of Wales College of Medicine, Cardiff, U.K.

PMID: 2752367
DOI: 10.1016/0165-4608(89)90178-7

Abstract

We describe a further case of Philadelphia chromosome-positive chronic myeloid leukemia with a t(3;21)(q26.2;q22) present in the chronic phase. Blastic transformation occurred 8 months after presentation. The presence of the t(3;21) may indicate a poor prognosis.

Publication types

Case Reports

MeSH terms

Adult
Chromosomes, Human, Pair 21*
Chromosomes, Human, Pair 3*
Female
Humans
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
Leukemia, Myeloid, Chronic-Phase / genetics*
Prognosis
Time Factors
Translocation, Genetic*