KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma

Bizunesh Abere; Thomas F Schulz

doi:10.1016/j.coviro.2016.07.008

KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma

Curr Opin Virol. 2016 Oct:20:11-19. doi: 10.1016/j.coviro.2016.07.008. Epub 2016 Aug 9.

Authors

Bizunesh Abere¹, Thomas F Schulz²

Affiliations

¹ Institute of Virology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany; German Centre for Infection Research, Hannover-Braunschweig Site, Germany.
² Institute of Virology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany; German Centre for Infection Research, Hannover-Braunschweig Site, Germany. Electronic address: schulz.thomas@mh-hannover.de.

PMID: 27518127
DOI: 10.1016/j.coviro.2016.07.008

Abstract

Kaposi's sarcoma (KS) is an unusual neoplasm characterized by extensive neoangiogenesis, infiltrates of inflammatory cells and atypically differentiated spindle cells of endothelial origin. KS is caused by an oncogenic γ-herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 (HHV-8). Several KSHV proteins can subvert multiple cellular angiogenic, mitogenic and inflammatory pathways. Here, we discuss the KSHV encoded membrane proteins vGPCR, K1 and K15, with a particular emphasis on their activation of cellular signaling pathways and their role in the development of specific features of KS.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinogenesis*
Herpesvirus 8, Human / pathogenicity*
Humans
Receptors, Chemokine / metabolism*
Sarcoma, Kaposi / physiopathology*
Signal Transduction*
Viral Proteins / metabolism*

Substances

G protein-coupled receptor, Human herpesvirus 8
K1 protein, Human herpesvirus 8
K15 protein, Human herpesvirus 8
Receptors, Chemokine
Viral Proteins