Supramolecular Metallo-Bioadhesive for Minimally Invasive Use

Seonki Hong; David Pirovich; Aoife Kilcoyne; Chen-Han Huang; Hakho Lee; Ralph Weissleder

doi:10.1002/adma.201602606

Supramolecular Metallo-Bioadhesive for Minimally Invasive Use

Adv Mater. 2016 Oct;28(39):8675-8680. doi: 10.1002/adma.201602606. Epub 2016 Aug 12.

Authors

Seonki Hong¹, David Pirovich¹, Aoife Kilcoyne^{1

2}, Chen-Han Huang¹, Hakho Lee¹, Ralph Weissleder^{3

4

5}

Affiliations

¹ Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St., CPZN 5206, Boston, MA, 02114, USA.
² Division of Interventional Radiology, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA.
³ Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St., CPZN 5206, Boston, MA, 02114, USA. rweissleder@mgh.harvard.edu.
⁴ Division of Interventional Radiology, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA. rweissleder@mgh.harvard.edu.
⁵ Department of Systems Biology, Harvard Medical School, 200 Longwood Ave., Boston, MA, 02115, USA. rweissleder@mgh.harvard.edu.

Abstract

A novel metallo-bioadhesive to be used as tissue sealant in minimally invasive procedures is reported. Metal complexation can be used to render gelatin derivatives adhesive, which occurs in minutes, is efficient, and fully biodegradable within weeks.

Keywords: catechol-conjugated polymers; image-guided intervention; metal-ligand complexation; sealants; surgery; tissue adhesives.

MeSH terms

Gelatin
Tissue Adhesives*

Substances

Tissue Adhesives
Gelatin

Grants and funding

R01 EB010011/EB/NIBIB NIH HHS/United States