Microthymoma in elderly-onset myasthenia gravis detected preoperatively

Asian Cardiovasc Thorac Ann. 2016 Oct;24(8):818-821. doi: 10.1177/0218492316665057. Epub 2016 Aug 10.

Abstract

A 77-year-old woman with a 3-month history of muscle weakness was diagnosed with elderly-onset generalized myasthenia gravis (Myasthenia Gravis Foundation of America classification IIa) based on a high serum acetylcholine receptor antibody level (25.4 nmol·L-1) and neurological findings. Computed tomography detected a small nodule (diameter 15 mm) in the anterior mediastinum, which was suspected to be a thymoma. An extended thymectomy was performed. The pathological examination revealed a 6-mm-diameter thymoma, termed a microthymoma, accompanied with a unilocular thymic cyst without capsule formation (type B2 according to the World Health Organization classification). Some fat tissue was also found within the tumor.

Keywords: Aging; Mediastinal cyst; Myasthenia gravis; Thymectomy; Thymoma; Thymus neoplasms.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biomarkers, Tumor / analysis
  • Biopsy
  • Female
  • Humans
  • Immunohistochemistry
  • Myasthenia Gravis / complications*
  • Myasthenia Gravis / diagnosis
  • Myasthenia Gravis / surgery
  • Thymectomy
  • Thymoma / chemistry
  • Thymoma / complications*
  • Thymoma / diagnostic imaging
  • Thymoma / surgery
  • Thyroid Neoplasms / chemistry
  • Thyroid Neoplasms / complications*
  • Thyroid Neoplasms / diagnostic imaging
  • Thyroid Neoplasms / surgery
  • Thyroid Nodule / chemistry
  • Thyroid Nodule / complications*
  • Thyroid Nodule / diagnostic imaging
  • Thyroid Nodule / surgery
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Tumor Burden

Substances

  • Biomarkers, Tumor