Lymphoblastic leukemia with surface light chain restriction: A diagnostic dilemma

Nikhil Rabade; Asma Bibi; Kiran Ghodke; Nikhil Patkar; Prashant Tembhare; Pratibha Amare; P G Subramanian; Sumeet Gujral

doi:10.4103/0377-4929.188129

Lymphoblastic leukemia with surface light chain restriction: A diagnostic dilemma

Indian J Pathol Microbiol. 2016 Jul-Sep;59(3):410-2. doi: 10.4103/0377-4929.188129.

Authors

Nikhil Rabade¹, Asma Bibi¹, Kiran Ghodke¹, Nikhil Patkar¹, Prashant Tembhare¹, Pratibha Amare², P G Subramanian¹, Sumeet Gujral¹

Affiliations

¹ Department of Pathology, Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, Maharashtra, India.
² Department of Cancer Cytogenetics, Tata Memorial Hospital, Mumbai, Maharashtra, India.

PMID: 27510693
DOI: 10.4103/0377-4929.188129

Abstract

Surface light chain expression is a feature of mature B-cell neoplasms. Light chain restriction in precursor B acute lymphoblastic leukemia is infrequently seen. We report a case of a 28-year-old female with non-FAB L3 morphology blasts and immunophenotypic features showing overlap between a precursor and mature B-cell neoplasm.

Publication types

Case Reports

MeSH terms

Adult
Female
Humans
Immunoglobulin Light Chains / biosynthesis*
Immunophenotyping
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
Precursor Cells, B-Lymphoid / chemistry*
Receptors, Antigen, B-Cell / biosynthesis*

Substances

Immunoglobulin Light Chains
Receptors, Antigen, B-Cell