Regulation of Plexin: A Ring of Structural Twists and Turns

Neuron. 2016 Aug 3;91(3):497-9. doi: 10.1016/j.neuron.2016.07.022.

Abstract

The regulation of the guidance receptor plexin is incompletely understood. In this issue, Kong et al. (2016) present crystal structures of the full-length extracellular region of class A plexins, revealing its dual role in both autoinhibition and activation.

Keywords: activation; autoinhibition; axon guidance; dimerization; plexin; structure.

MeSH terms

  • Cell Adhesion Molecules / chemistry*
  • Nerve Tissue Proteins / chemistry*
  • Receptors, Cell Surface / chemistry
  • Semaphorins
  • Signal Transduction

Substances

  • Cell Adhesion Molecules
  • Nerve Tissue Proteins
  • Receptors, Cell Surface
  • Semaphorins
  • plexin