Management of Hormone Deprivation Symptoms After Cancer

Mayo Clin Proc. 2016 Aug;91(8):1133-46. doi: 10.1016/j.mayocp.2016.04.009.

Abstract

Cancer survivors often experience symptoms related to hormone deprivation, including vasomotor symptoms, genitourinary symptoms, and sexual health concerns. These symptoms can occur due to natural menopause in midlife women, or they can be brought on by oncologic therapies in younger women or men. We searched PubMed for English-language studies from January 1990 through January 2016 to identify relevant articles on the management of hormone deprivation symptoms, including vasomotor, genitourinary, and sexual symptoms in patients with cancer. The search terms used included hormone deprivation, vasomotor symptoms, hot flash, vaginal dryness, sexual dysfunction, and breast cancer. This manuscript provides a comprehensive description of data supporting the treatment of symptoms associated with hormone deprivation.

Publication types

  • Review

MeSH terms

  • Adrenergic alpha-2 Receptor Agonists / therapeutic use
  • Anti-Anxiety Agents / therapeutic use
  • Antidepressive Agents / therapeutic use
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Cholinergic Antagonists / therapeutic use
  • Cognitive Behavioral Therapy
  • Estrogens / adverse effects
  • Estrogens / therapeutic use
  • Female
  • Female Urogenital Diseases / chemically induced*
  • Female Urogenital Diseases / therapy
  • Gonadal Steroid Hormones / deficiency*
  • Hormone Replacement Therapy / adverse effects*
  • Hormone Replacement Therapy / standards
  • Hot Flashes / etiology
  • Hot Flashes / therapy
  • Humans
  • Male
  • Male Urogenital Diseases / chemically induced*
  • Male Urogenital Diseases / therapy
  • Neoplasms / complications*
  • Neoplasms / diet therapy
  • Progesterone / adverse effects
  • Progesterone / analogs & derivatives
  • Progesterone / therapeutic use
  • Sexual Dysfunction, Physiological / chemically induced*
  • Sexual Dysfunction, Physiological / therapy
  • Survivors
  • Vasomotor System / drug effects*
  • Vasomotor System / physiopathology

Substances

  • Adrenergic alpha-2 Receptor Agonists
  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Antineoplastic Agents
  • Cholinergic Antagonists
  • Estrogens
  • Gonadal Steroid Hormones
  • Progesterone