[Sinonasal fungal infections are not exclusively due to mucorales and Aspergillus!]

Ann Pathol. 2016 Aug;36(4):245-51. doi: 10.1016/j.annpat.2016.04.005. Epub 2016 Jul 27.
[Article in French]

Abstract

Rhino-sinusal infections are serious diseases and possibly lethal. When they are invasive, we easily discuss apergilloses and mucormycoses. The confirmation of the diagnosis of mucormycosis need an extensive surgery for precise histopathological and mycological evaluation. The pathologist may be faced to other rare mycoses such as phaeohyphomycoses, which present different morphological features than mucormycoses and Aspergillus. Once the diagnosis is established, an appropriate antifungal treatment is quickly started. The aim of our work is to report two observations of phaeohyphomycoses, to describe their histopathological features, to discuss complementary diagnostic methods and to present the main differential diagnoses.

Keywords: Alternaria; Aspergillose; Aspergillosis; Invasive; Mucormycose; Mucormycosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Alternaria / isolation & purification*
  • Alternaria / ultrastructure
  • Alternariosis / diagnosis
  • Alternariosis / microbiology*
  • Alternariosis / pathology
  • Alternariosis / therapy
  • Amphotericin B / administration & dosage
  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Combined Modality Therapy
  • Debridement
  • Diagnosis, Differential
  • Early Diagnosis
  • Fatal Outcome
  • Female
  • Humans
  • Liposomes
  • Mastoiditis / drug therapy
  • Mastoiditis / microbiology
  • Mastoiditis / surgery
  • Phaeohyphomycosis / diagnosis
  • Phaeohyphomycosis / microbiology*
  • Phaeohyphomycosis / pathology
  • Phaeohyphomycosis / therapy
  • Postoperative Complications / etiology
  • Retrospective Studies
  • Rhinitis / diagnosis
  • Rhinitis / microbiology*
  • Rhinitis / pathology
  • Rhinitis / therapy
  • Shock, Septic / etiology
  • Sinusitis / diagnosis
  • Sinusitis / microbiology*
  • Sinusitis / pathology
  • Sinusitis / therapy

Substances

  • Antifungal Agents
  • Liposomes
  • liposomal amphotericin B
  • Amphotericin B