Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium

David C Binder; Ainhoa Arina; Frank Wen; Tony Tu; Ming Zhao; Robert M Hoffman; Derek A Wainwright; Hans Schreiber

doi:10.1080/2162402X.2015.1130207

Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium

Oncoimmunology. 2016 Feb 18;5(6):e1130207. doi: 10.1080/2162402X.2015.1130207. eCollection 2016 Jun.

Authors

David C Binder¹, Ainhoa Arina², Frank Wen³, Tony Tu², Ming Zhao⁴, Robert M Hoffman⁵, Derek A Wainwright⁶, Hans Schreiber⁷

Affiliations

¹ Committee on Cancer Biology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA.
² Department of Pathology, University of Chicago, Chicago, IL, USA; Committee on Immunology, The University of Chicago, Chicago, IL, USA.
³ Department of Pathology, University of Chicago , Chicago, IL, USA.
⁴ AntiCancer Inc. , San Diego, CA, USA.
⁵ AntiCancer Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USA.
⁶ Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Northwestern Brain Tumor Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
⁷ Committee on Cancer Biology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA; Committee on Immunology, The University of Chicago, Chicago, IL, USA.

Abstract

We recently reported that therapeutic vaccination with live tumor antigen-producing Salmonella typhimurium rescues dysfunctional endogenous T cell responses and eradicates long-established tumors refractory to αCTLA-4 and αPD-L1 checkpoint inhibitor blockade. Here, we show that live intravenously injected or heat-killed (HK) intratumorally injected Salmonella typhimurium, even when not producing tumor antigen, synergize with adoptive T cell therapy to eradicate tumors. These data demonstrate that the combination of adoptive T cell transfer with the injection of live or dead Salmonella typhimurium is a promising approach for cancer treatment.

Keywords: Adoptive T cell therapy; bacteria; macrophage; relapse; tumor stroma.

Publication types

Research Support, N.I.H., Extramural

Abstract

Publication types

Grants and funding