Intracranial Inflammatory Myofibroblastic Tumor with Sarcomatous Local Recurrence

World Neurosurg. 2016 Sep:93:484.e1-4. doi: 10.1016/j.wneu.2016.07.060. Epub 2016 Jul 25.

Abstract

Case description: A 20-year-old woman presented with a rare intracranial inflammatory myofibroblastic tumor (IMT) manifesting as headache and insomnia. Magnetic resonance imaging showed a tumorous lesion with heterogeneous enhancement at the right temporal lobe, as well as perifocal edema with midline shift. The tumor was totally resected with the margin free. Pathologic examination showed IMT with myofibroblastic cells admixed with collagen fibers. Sarcomatous change in morphology was observed in tumor recurrence within 7 months.

Conclusions: Surgical resection and whole brain radiation are recommended in patients with IMT.

Keywords: Anaplastic lymphoma kinase; Brain; Inflammatory myofibroblastic tumor; Recurrence; Sarcomatous change.

Publication types

  • Case Reports

MeSH terms

  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / surgery*
  • Cell Transformation, Neoplastic / pathology
  • Craniotomy / methods
  • Diagnosis, Differential
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Recurrence, Local / radiotherapy*
  • Neoplasms, Muscle Tissue / diagnostic imaging
  • Neoplasms, Muscle Tissue / pathology*
  • Neoplasms, Muscle Tissue / surgery*
  • Radiotherapy, Adjuvant / methods
  • Sarcoma / prevention & control*
  • Treatment Outcome
  • Young Adult